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Results (30 reactions)

RHEA:25282 squalene + reduced [NADPH—hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH—hemoprotein reductase] + H2O + H+ 5,570 protein(s) (UniProtKB)
RHEA:33447 4β-methylzymosterol-4α-carboxylate + NADP+ = 3-dehydro-4-methylzymosterol + CO2 + NADPH
  • EC:1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
7 protein(s) (UniProtKB)
RHEA:33455 4α-carboxyzymosterol + NADP+ = zymosterone + CO2 + NADPH
4 protein(s) (UniProtKB)
RHEA:33459 zymosterone + NADPH + H+ = zymosterol + NADP+
3 protein(s) (UniProtKB)
RHEA:33919 lanosterol + NADPH + H+ = 24,25-dihydrolanosterol + NADP+
4 protein(s) (UniProtKB)
RHEA:33999 zymosterol = 5α-cholesta-7,24-dien-3β-ol
5 protein(s) (UniProtKB)
RHEA:34003 5α-cholesta-7,24-dien-3β-ol + NADPH + O2 + H+ = 7-dehydrodesmosterol + NADP+ + 2 H2O
RHEA:36379 3-dehydro-4α-methylzymosterol + NADPH + H+ = 4α-methylzymosterol + NADP+ 369 protein(s) (UniProtKB)
RHEA:36391 cholesterol + NADP+ = desmosterol + NADPH + H+ 4 protein(s) (UniProtKB)
RHEA:36395 7-dehydrocholesterol + NADP+ = 7-dehydrodesmosterol + NADPH + H+
RHEA:36399 5α-cholest-8-en-3β-ol + NADP+ = zymosterol + NADPH + H+ 4 protein(s) (UniProtKB)
RHEA:45960 24,25-dihydrolanosterol + 3 reduced [NADPH—hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3β-ol + formate + 3 oxidized [NADPH—hemoprotein reductase] + 4 H2O + 4 H+
1,468 protein(s) (UniProtKB)
RHEA:46472 4α-methylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = 4α-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46476 4α-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = 4α-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46480 4α-formylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + H+ = 4α-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:47056 4α-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H+ = 4α-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O
8 protein(s) (UniProtKB)
RHEA:47060 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = 4α-hydroxymethyl-4β-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:47064 4α-hydroxymethyl-4β-methylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = 4β-methylzymosterol-4α-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:47068 4β-methylzymosterol-4α-carbaldehyde + 2 Fe(II)-[cytochrome b5] + O2 + H+ = 4β-methylzymosterol-4α-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:47160 4β-methylzymosterol-4α-carboxylate + NAD+ = 3-dehydro-4-methylzymosterol + CO2 + NADH
4 protein(s) (UniProtKB)
RHEA:47164 4α-carboxyzymosterol + NAD+ = zymosterone + CO2 + NADH
4 protein(s) (UniProtKB)
RHEA:47184 5α-cholesta-7,24-dien-3β-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
3 protein(s) (UniProtKB)
RHEA:55244 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H+ = 4β-methylzymosterol-4α-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O
8 protein(s) (UniProtKB)
RHEA:62768 4α-methyl-5α-cholest-7-en-3β-ol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H+ = 4α-carboxy-5α-cholest-7-en-3β-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
6 protein(s) (UniProtKB)
RHEA:75079 24,25-dihydrolanosterol + reduced [NADPH—hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1,468 protein(s) (UniProtKB)
RHEA:75103 lanosterol + reduced [NADPH—hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1,970 protein(s) (UniProtKB)
RHEA:75107 32-hydroxylanosterol + reduced [NADPH—hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH—hemoprotein reductase] + 2 H2O + H+
1,970 protein(s) (UniProtKB)
RHEA:75111 32-oxolanosterol + reduced [NADPH—hemoprotein reductase] + O2 = 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol + formate + oxidized [NADPH—hemoprotein reductase] + H2O + 2 H+
1,970 protein(s) (UniProtKB)
RHEA:13685 lathosterol + NADP+ = 5α-cholesta-7,24-dien-3β-ol + NADPH + H+ 2 protein(s) (UniProtKB)
RHEA:14621 (S)-2,3-epoxysqualene = lanosterol 13 protein(s) (UniProtKB)