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Results (83 reactions)

RHEA:23728 (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O 567 protein(s) (UniProtKB)
RHEA:26132 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
2,275 protein(s) (UniProtKB)
RHEA:26136 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate 416 protein(s) (UniProtKB)
RHEA:32307 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O 4 protein(s) (UniProtKB)
RHEA:38675 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
5 protein(s) (UniProtKB)
RHEA:39755 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
15 protein(s) (UniProtKB)
RHEA:39759 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
611 protein(s) (UniProtKB)
RHEA:39811 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
14 protein(s) (UniProtKB)
RHEA:40151 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H+
10,457 protein(s) (UniProtKB)
RHEA:40427 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
1,451 protein(s) (UniProtKB)
RHEA:40431 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
305 protein(s) (UniProtKB)
RHEA:40451 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
259 protein(s) (UniProtKB)
RHEA:40519 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
266 protein(s) (UniProtKB)
RHEA:40579 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
4 protein(s) (UniProtKB)
RHEA:40647 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
10 protein(s) (UniProtKB)
RHEA:40651 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
5 protein(s) (UniProtKB)
RHEA:40759 1-hexadecanoylglycerone 3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate
RHEA:40827 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
7 protein(s) (UniProtKB)
RHEA:40831 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
4 protein(s) (UniProtKB)
RHEA:41067 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
267 protein(s) (UniProtKB)
RHEA:41075 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
259 protein(s) (UniProtKB)
RHEA:41215 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
3 protein(s) (UniProtKB)
RHEA:41247 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:41271 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 2-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
261 protein(s) (UniProtKB)
RHEA:41336 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
3 protein(s) (UniProtKB)
RHEA:42280 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
214 protein(s) (UniProtKB)
RHEA:42284 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
214 protein(s) (UniProtKB)
RHEA:42596 (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2
566 protein(s) (UniProtKB)
RHEA:44500 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
6 protein(s) (UniProtKB)
RHEA:44520 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
6 protein(s) (UniProtKB)
RHEA:44540 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
6 protein(s) (UniProtKB)
RHEA:44728 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
23 protein(s) (UniProtKB)
RHEA:45348 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine + H2O = sphing-4-enine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
2 protein(s) (UniProtKB)
RHEA:45376 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine + H2O = sphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
2 protein(s) (UniProtKB)
RHEA:45380 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
2 protein(s) (UniProtKB)
RHEA:48736 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:48832 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
1 protein(s) (UniProtKB)
RHEA:48844 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
2 protein(s) (UniProtKB)
RHEA:49856 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
196 protein(s) (UniProtKB)
RHEA:49860 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
613 protein(s) (UniProtKB)
RHEA:49876 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
10 protein(s) (UniProtKB)
RHEA:49880 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
25 protein(s) (UniProtKB)
RHEA:49884 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
24 protein(s) (UniProtKB)
RHEA:49928 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
3 protein(s) (UniProtKB)
RHEA:49936 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:49968 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
12 protein(s) (UniProtKB)
RHEA:49972 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
12 protein(s) (UniProtKB)
RHEA:50852 (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
214 protein(s) (UniProtKB)
RHEA:50856 (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
214 protein(s) (UniProtKB)
RHEA:50924 (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
7 protein(s) (UniProtKB)
RHEA:50928 (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
7 protein(s) (UniProtKB)
RHEA:51312 (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
1,466 protein(s) (UniProtKB)
RHEA:51444 L-leucine + (5Z,8Z,11Z,14Z)-eicosatetraenoate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine + H2O
RHEA:51472 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
4 protein(s) (UniProtKB)
RHEA:51480 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
4 protein(s) (UniProtKB)
RHEA:51484 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:52288 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:52292 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
15 protein(s) (UniProtKB)
RHEA:52296 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
2 protein(s) (UniProtKB)
RHEA:52300 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:52492 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:52496 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:52508 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:53308 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:53312 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
1 protein(s) (UniProtKB)
RHEA:63016 (5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4+
4 protein(s) (UniProtKB)
RHEA:63052 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = methanol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
4 protein(s) (UniProtKB)
RHEA:63284 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:63288 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
1 protein(s) (UniProtKB)
RHEA:63308 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
1 protein(s) (UniProtKB)
RHEA:63432 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
3 protein(s) (UniProtKB)
RHEA:64108 N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
1,471 protein(s) (UniProtKB)
RHEA:64116 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
1,471 protein(s) (UniProtKB)
RHEA:64220 N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + H2O = taurine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
RHEA:64984 (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH—hemoprotein reductase] + O2 = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH—hemoprotein reductase] + H2O + H+
RHEA:71395 (5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
8 protein(s) (UniProtKB)
RHEA:74159 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
3 protein(s) (UniProtKB)
RHEA:79915 (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-α-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-β-D-glucuronate + UDP
14 protein(s) (UniProtKB)
RHEA:10428 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate 16 protein(s) (UniProtKB)
RHEA:14985 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate 1 protein(s) (UniProtKB)
RHEA:16869 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate 13 protein(s) (UniProtKB)
RHEA:17485 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
4 protein(s) (UniProtKB)
RHEA:19713 (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate 7,976 protein(s) (UniProtKB)