Reaction participants Show >> << Hide
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Name help_outline
5-methoxy-2-methyl-3-all-trans-polyprenyl-1,4-benzoquinol
Identifier
CHEBI:84167
Charge
0
Formula
(C5H8)nC8H10O3
Search links
Involved in 11 reaction(s)
Find proteins in UniProtKB for this molecule
Form(s) in this reaction:
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Identifier: RHEA-COMP:10859Polymer name: a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diolPolymerization index help_outline nFormula C8H10O3(C5H8)nCharge (0)(0)nMol File for the polymer
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- Name help_outline A Identifier CHEBI:13193 Charge Formula R SMILEShelp_outline * 2D coordinates Mol file for the small molecule Search links Involved in 2,937 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Name help_outline
a 2-methoxy-5-methyl-6-all-trans-polyprenyl-1,4-benzoquinone
Identifier
CHEBI:231829
Charge
0
Formula
(C5H8)n.C8H8O3
Search links
Involved in 3 reaction(s)
Find proteins in UniProtKB for this molecule
Form(s) in this reaction:
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Identifier: RHEA-COMP:19655Polymer name: a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinonePolymerization index help_outline nFormula C8H8O3(C5H8)nCharge (0)(0)nMol File for the polymer
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- Name help_outline AH2 Identifier CHEBI:17499 Charge 0 Formula RH2 SMILEShelp_outline *([H])[H] 2D coordinates Mol file for the small molecule Search links Involved in 2,865 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:81207 | RHEA:81208 | RHEA:81209 | RHEA:81210 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis.
Nicoll C.R., Alvigini L., Gottinger A., Cecchini D., Mannucci B., Corana F., Mascotti M.L., Mattevi A.
Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is currently attributed to ten different proteins, with COQ3 ... >> More
Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is currently attributed to ten different proteins, with COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9 forming the iconic COQ metabolon. Yet several reaction steps conducted by the metabolon remain enigmatic. To elucidate the prerequisites for animal coenzyme Q biosynthesis, we sought to construct the entire metabolon in vitro. Here we show that this approach, rooted in ancestral sequence reconstruction, reveals the enzymes responsible for the uncharacterized steps and captures the biosynthetic pathway in vitro. We demonstrate that COQ8, a kinase, increases and streamlines coenzyme Q production. Our findings provide crucial insight into how biocatalytic efficiency is regulated and enhanced by these biosynthetic engines in the context of the cell. << Less
Nat Catal 7:148-160(2024) [PubMed] [EuropePMC]
This publication is cited by 22 other entries.