Reaction participants Show >> << Hide
- Name help_outline streptomycin Identifier CHEBI:58007 Charge 3 Formula C21H42N7O12 InChIKeyhelp_outline UCSJYZPVAKXKNQ-HZYVHMACSA-Q SMILEShelp_outline C[NH2+][C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=[NH2+])[C@@H](O)[C@@H]1NC(N)=[NH2+] 2D coordinates Mol file for the small molecule Search links Involved in 6 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline GTP Identifier CHEBI:37565 (Beilstein: 5211792) help_outline Charge -4 Formula C10H12N5O14P3 InChIKeyhelp_outline XKMLYUALXHKNFT-UUOKFMHZSA-J SMILEShelp_outline Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 94 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 6-O-guanylylstreptomycin Identifier CHEBI:184374 Charge 2 Formula C31H53N12O19P InChIKeyhelp_outline DLHWUVGNCLQQJH-PSFJNKIMSA-P SMILEShelp_outline C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C3=C(C(NC(=N3)N)=O)N=C2)OP(O[C@H]4[C@@H]([C@H]([C@@H]([C@H]([C@@H]4O)O[C@@H]5O[C@H]([C@@]([C@H]5O[C@@H]6O[C@H]([C@@H]([C@H]([C@@H]6[NH2+]C)O)O)CO)(C=O)O)C)NC(=[NH2+])N)O)NC(N)=[NH2+])(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) help_outline Charge -3 Formula HO7P2 InChIKeyhelp_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILEShelp_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,139 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:69540 | RHEA:69541 | RHEA:69542 | RHEA:69543 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase.
Corzana F., Cuesta I., Bastida A., Hidalgo A., Latorre M., Gonzalez C., Garcia-Junceda E., Jimenez-Barbero J., Asensio J.L.
The molecular recognition of streptomycin by Bacillus subtilis aminoglycoside-6-adenyl transferase has been analysed by a combination of NMR techniques and molecular dynamic simulations. This protein inactivates streptomycin by transferring an adenyl group to position six of the streptidine moiety ... >> More
The molecular recognition of streptomycin by Bacillus subtilis aminoglycoside-6-adenyl transferase has been analysed by a combination of NMR techniques and molecular dynamic simulations. This protein inactivates streptomycin by transferring an adenyl group to position six of the streptidine moiety. Our combined approach provides valuable information about the bioactive conformation for both the antibiotic and ATP and shows that the molecular recognition process for streptomycin involves a conformational selection phenomenon. The binding epitope for both ligands has also been analysed by 1D-STD experiments. Finally, the specificity of the recognition process with respect to the aminoglycoside and to the nucleotide has been studied. << Less
Chemistry 11:5102-5113(2005) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.