Enzymes
| UniProtKB help_outline | 969 proteins |
Reaction participants Show >> << Hide
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Namehelp_outline
ribonucleotidyl-uridine-RNA
Identifier
RHEA-COMP:17354
Reactive part
help_outline
- Name help_outline ribonucleotide-uridine residue Identifier CHEBI:173117 Charge -2 Formula C14H17N2O14P2R SMILEShelp_outline *[C@@H]1O[C@H](COP(*)(=O)[O-])[C@H]([C@H]1O)OP(OC[C@H]2O[C@@H](N3C(=O)NC(C=C3)=O)[C@@H]([C@@H]2O*)O)([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA
Identifier
RHEA-COMP:10464
Reactive part
help_outline
- Name help_outline a 3'-terminal ribonucleotide 2',3'-cyclic phosphate residue Identifier CHEBI:83064 Charge -2 Formula C5H6O8P2R SMILEShelp_outline [O-]P(-*)(=O)OC[C@H]1O[C@@H]([*])[C@@H]2OP([O-])(=O)O[C@H]12 2D coordinates Mol file for the small molecule Search links Involved in 7 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
a 5'-end dephospho-uridine-RNA
Identifier
RHEA-COMP:17356
Reactive part
help_outline
- Name help_outline 5'-dephospho-uridine residue Identifier CHEBI:173224 Charge 0 Formula C9H11N2O6 SMILEShelp_outline OC[C@H]1O[C@@H](N2C(=O)NC(C=C2)=O)[C@@H]([C@@H]1O*)O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:67792 | RHEA:67793 | RHEA:67794 | RHEA:67795 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Related reactions help_outline
More general form(s) of this reaction
Publications
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The tumor marker human placental protein 11 is an endoribonuclease.
Laneve P., Gioia U., Ragno R., Altieri F., Di Franco C., Santini T., Arceci M., Bozzoni I., Caffarelli E.
Human PP11 (placental protein 11) was previously described as a serine protease specifically expressed in the syncytiotrophoblast and in numerous tumor tissues. Several PP11-like proteins were annotated in distantly related organisms, such as worms and mammals, suggesting their involvement in evol ... >> More
Human PP11 (placental protein 11) was previously described as a serine protease specifically expressed in the syncytiotrophoblast and in numerous tumor tissues. Several PP11-like proteins were annotated in distantly related organisms, such as worms and mammals, suggesting their involvement in evolutionarily conserved processes. Based on sequence similarity, human PP11 was included in a protein family whose characterized members are XendoU, a Xenopus laevis endoribonuclease involved in small nucleolar RNA processing, and Nsp15, an endoribonuclease essential for coronavirus replication. Here we show that the bacterially expressed human PP11 displays RNA binding capability and cleaves single stranded RNA in a Mn(2+)-dependent manner at uridylates, to produce molecules with 2',3'-cyclic phosphate ends. These features, together with structural and mutagenesis analyses, which identified the potential active site residues, reveal striking parallels to the amphibian XendoU and assign a ribonuclease function to PP11. This newly discovered enzymatic activity places PP11-like proteins in a completely new perspective. << Less
J. Biol. Chem. 283:34712-34719(2008) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.