Enzymes
| UniProtKB help_outline | 1 proteins |
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- Name help_outline (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate Identifier CHEBI:167912 Charge -2 Formula C25H33NO6 InChIKeyhelp_outline XWIZBMORQRLANJ-NPPXQRPRSA-M SMILEShelp_outline C([C@@H](C/C=C/C=C/C(/C)=C/C)C)[C@H](/C=C/C([C-]1C([C@@H](NC1=O)C[C@@](C(=O)[O-])(C)O)=O)=O)C 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline sch 210971 Identifier CHEBI:167911 Charge -2 Formula C25H33NO6 InChIKeyhelp_outline AVZATKWNGXCSDN-UGIHOUBQSA-L SMILEShelp_outline C1[C@@H](C[C@]2([C@]([C@@H]1C)([C@H]([C@](C=C2)(/C(/C)=C/C)[H])/C(/[O-])=C/3\C([C@@H](NC3=O)C[C@@](C(=O)[O-])(C)O)=O)[H])[H])C 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:67320 | RHEA:67321 | RHEA:67322 | RHEA:67323 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Biosynthesis of the tetramic acids Sch210971 and Sch210972.
Kakule T.B., Zhang S., Zhan J., Schmidt E.W.
A biosynthetic pathway to fungal polyketide-nonribosomal peptide natural products, Sch210971 (1a) and Sch210972 (1b) from Hapsidospora irregularis, was characterized by reconstitution and heterologous expression in Fusarium heterosporum. Using genetic, biochemical, and feeding experiments, we show ... >> More
A biosynthetic pathway to fungal polyketide-nonribosomal peptide natural products, Sch210971 (1a) and Sch210972 (1b) from Hapsidospora irregularis, was characterized by reconstitution and heterologous expression in Fusarium heterosporum. Using genetic, biochemical, and feeding experiments, we show that the incorporated amino acid 4-hydroxyl-4-methyl glutamate (HMG) is synthesized by an aldolase, probably using pyruvate as the precursor. << Less
Org. Lett. 17:2295-2297(2015) [PubMed] [EuropePMC]
This publication is cited by 3 other entries.