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Enzymes

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Name ^help_outline (E)-non-2-enal Identifier CHEBI:142592 (CAS: 18829-56-6) ^help_outline Charge 0 Formula C9H16O InChIKey^help_outline BSAIUMLZVGUGKX-BQYQJAHWSA-N SMILES^help_outline CCCCCC/C=C/C(=O)[H] 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline NADP⁺ Identifier CHEBI:58349 Charge -3 Formula C21H25N7O17P3 InChIKey^help_outline XJLXINKUBYWONI-NNYOXOHSSA-K SMILES^help_outline NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,294 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H₂O Identifier CHEBI:15377 (CAS: 7732-18-5) ^help_outline Charge 0 Formula H2O InChIKey^help_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILES^help_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,264 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline (E)-non-2-enoate Identifier CHEBI:143908 Charge -1 Formula C9H15O2 InChIKey^help_outline ADLXTJMPCFOTOO-BQYQJAHWSA-M SMILES^help_outline CCCCCC/C=C/C(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline NADPH Identifier CHEBI:57783 (Beilstein: 10411862) ^help_outline Charge -4 Formula C21H26N7O17P3 InChIKey^help_outline ACFIXJIJDZMPPO-NNYOXOHSSA-J SMILES^help_outline NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,288 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H⁺ Identifier CHEBI:15378 Charge 1 Formula H InChIKey^help_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILES^help_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,521 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:60692	RHEA:60693	RHEA:60694	RHEA:60695
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline	5 proteins	5 proteins

Related reactions ^help_outline

More general form(s) of this reaction

RHEA:80815
a medium-chain fatty aldehyde + NADP⁺ + H₂O = a medium-chain fatty acid + NADPH + 2 H⁺

Publications

Expression and initial characterization of human ALDH3B1.

Marchitti S.A., Orlicky D.J., Vasiliou V.

Aldehyde dehydrogenases (ALDHs) are critical enzymes in the metabolism of endogenous and exogenous aldehydes. The human genome contains 19 putatively functional ALDH genes; ALDH3B1 belongs to the ALDH3 family. While recent studies have linked the ALDH3B1 locus to schizophrenia, nothing was known, ... >> More

Aldehyde dehydrogenases (ALDHs) are critical enzymes in the metabolism of endogenous and exogenous aldehydes. The human genome contains 19 putatively functional ALDH genes; ALDH3B1 belongs to the ALDH3 family. While recent studies have linked the ALDH3B1 locus to schizophrenia, nothing was known, until now, about the properties and significance of the ALDH3B1 protein. The aim of this study was to characterize the ALDH3B1 protein. Human ALDH3B1 was baculovirus-expressed and found to be catalytically active towards medium- and long-chain aliphatic aldehydes and the aromatic aldehyde benzaldehyde. Western blot analyses indicate that ALDH3B1 is highly expressed in kidney and liver and moderately expressed in various brain regions. ALDH3B1-transfected HEK293 cells were significantly protected against cytotoxicity induced by the lipid peroxidation product octanal when compared to vector-transfected cells. This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress. << Less

Biochem. Biophys. Res. Commun. 356:792-798(2007) [PubMed] [EuropePMC]

This publication is cited by 9 other entries.

Comments

Published in: Teoh K.H., Polichuk D.R., Reed D.W., Covello P.S. Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany 87:635-642 (2009)