Enzymes
| UniProtKB help_outline | 1 proteins |
| Enzyme class help_outline |
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Reaction participants Show >> << Hide
- Name help_outline aldehydo-D-apiose Identifier CHEBI:16689 (CAS: 639-97-4) help_outline Charge 0 Formula C5H10O5 InChIKeyhelp_outline AVGPOAXYRRIZMM-BYPYZUCNSA-N SMILEShelp_outline OCC(O)(CO)[C@@H](O)C=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline apulose Identifier CHEBI:141348 Charge 0 Formula C5H10O5 InChIKeyhelp_outline KNWXMEXZFWGIPP-UHFFFAOYSA-N SMILEShelp_outline C(O)C(=O)C(O)(CO)CO 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:56996 | RHEA:56997 | RHEA:56998 | RHEA:56999 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Functional assignment of multiple catabolic pathways for D-apiose.
Carter M.S., Zhang X., Huang H., Bouvier J.T., Francisco B.S., Vetting M.W., Al-Obaidi N., Bonanno J.B., Ghosh A., Zallot R.G., Andersen H.M., Almo S.C., Gerlt J.A.
Colocation of the genes encoding ABC, TRAP, and TCT transport systems and catabolic pathways for the transported ligand provides a strategy for discovering novel microbial enzymes and pathways. We screened solute-binding proteins (SBPs) for ABC transport systems and identified three that bind D-ap ... >> More
Colocation of the genes encoding ABC, TRAP, and TCT transport systems and catabolic pathways for the transported ligand provides a strategy for discovering novel microbial enzymes and pathways. We screened solute-binding proteins (SBPs) for ABC transport systems and identified three that bind D-apiose, a branched pentose in the cell walls of higher plants. Guided by sequence similarity networks (SSNs) and genome neighborhood networks (GNNs), the identities of the SBPs enabled the discovery of four catabolic pathways for D-apiose with eleven previously unknown reactions. The new enzymes include D-apionate oxidoisomerase, which catalyzes hydroxymethyl group migration, as well as 3-oxo-isoapionate-4-phosphate decarboxylase and 3-oxo-isoapionate-4-phosphate transcarboxylase/hydrolase, which are RuBisCO-like proteins (RLPs). The web tools for generating SSNs and GNNs are publicly accessible ( http://efi.igb.illinois.edu/efi-est/ ), so similar 'genomic enzymology' strategies for discovering novel pathways can be used by the community. << Less
Nat. Chem. Biol. 14:696-705(2018) [PubMed] [EuropePMC]
This publication is cited by 13 other entries.