Reaction participants Show >> << Hide
- Name help_outline benzylthiol Identifier CHEBI:137674 (CAS: 100-53-8) help_outline Charge 0 Formula C7H8S InChIKeyhelp_outline UENWRTRMUIOCKN-UHFFFAOYSA-N SMILEShelp_outline C1(=CC=CC=C1)CS 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline O2 Identifier CHEBI:15379 (CAS: 7782-44-7) help_outline Charge 0 Formula O2 InChIKeyhelp_outline MYMOFIZGZYHOMD-UHFFFAOYSA-N SMILEShelp_outline O=O 2D coordinates Mol file for the small molecule Search links Involved in 2,727 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline benzothialdehyde Identifier CHEBI:137675 Charge 0 Formula C7H6S InChIKeyhelp_outline ACOOSTZBTYEGER-UHFFFAOYSA-N SMILEShelp_outline C1(=CC=CC=C1)C=S 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O2 Identifier CHEBI:16240 (CAS: 7722-84-1) help_outline Charge 0 Formula H2O2 InChIKeyhelp_outline MHAJPDPJQMAIIY-UHFFFAOYSA-N SMILEShelp_outline [H]OO[H] 2D coordinates Mol file for the small molecule Search links Involved in 452 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:53792 | RHEA:53793 | RHEA:53794 | RHEA:53795 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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The oxidation of thiols by flavoprotein oxidases: a biocatalytic route to reactive thiocarbonyls.
Ewing T.A., Dijkman W.P., Vervoort J.M., Fraaije M.W., van Berkel W.J.
Flavoprotein oxidases are a diverse class of biocatalysts, most of which catalyze the oxidation of C-O, C-N, or C-C bonds. Flavoprotein oxidases that are known to catalyze the oxidation of C-S bonds are rare, being limited to enzymes that catalyze the oxidative cleavage of thioethers. Herein, we r ... >> More
Flavoprotein oxidases are a diverse class of biocatalysts, most of which catalyze the oxidation of C-O, C-N, or C-C bonds. Flavoprotein oxidases that are known to catalyze the oxidation of C-S bonds are rare, being limited to enzymes that catalyze the oxidative cleavage of thioethers. Herein, we report that various flavoprotein oxidases, previously thought to solely act on alcohols, also catalyze the oxidation of thiols to thiocarbonyls. These results highlight the versatility of enzymatic catalysis and provide a potential biocatalytic route to reactive thiocarbonyl compounds, which have a variety of applications in synthetic organic chemistry. << Less
Angew. Chem. Int. Ed. Engl. 53:13206-13209(2014) [PubMed] [EuropePMC]