Enzymes
| UniProtKB help_outline | 2 proteins |
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Reaction participants Show >> << Hide
- Name help_outline a jasmonyl-L-amino acid Identifier CHEBI:136183 Charge -1 Formula C14H19NO4R SMILEShelp_outline C1(C(CCC1=O)CC(N[C@H](C([O-])=O)*)=O)C/C=C\CC 2D coordinates Mol file for the small molecule Search links Involved in 8 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,204 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a jasmonate Identifier CHEBI:136184 Charge -1 Formula C12H17O3 InChIKeyhelp_outline ZNJFBWYDHIGLCU-ARJAWSKDSA-M SMILEShelp_outline C1(C(CCC1=O)CC([O-])=O)C/C=C\CC 2D coordinates Mol file for the small molecule Search links Involved in 9 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline an L-α-amino acid Identifier CHEBI:59869 Charge 0 Formula C2H4NO2R SMILEShelp_outline [NH3+][C@@H]([*])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 366 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:52028 | RHEA:52029 | RHEA:52030 | RHEA:52031 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Related reactions help_outline
Specific form(s) of this reaction
Publications
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The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves.
Widemann E., Miesch L., Lugan R., Holder E., Heinrich C., Aubert Y., Miesch M., Pinot F., Heitz T.
Jasmonates (JAs) are a class of signaling compounds that mediate complex developmental and adaptative responses in plants. JAs derive from jasmonic acid (JA) through various enzymatic modifications, including conjugation to amino acids or oxidation, yielding an array of derivatives. The main hormo ... >> More
Jasmonates (JAs) are a class of signaling compounds that mediate complex developmental and adaptative responses in plants. JAs derive from jasmonic acid (JA) through various enzymatic modifications, including conjugation to amino acids or oxidation, yielding an array of derivatives. The main hormonal signal, jasmonoyl-L-isoleucine (JA-Ile), has been found recently to undergo catabolic inactivation by cytochrome P450-mediated oxidation. We characterize here two amidohydrolases, IAR3 and ILL6, that define a second pathway for JA-Ile turnover during the wound response in Arabidopsis leaves. Biochemical and genetic evidence indicates that these two enzymes cleave the JA-Ile signal, but act also on the 12OH-JA-Ile conjugate. We also show that unexpectedly, the abundant accumulation of tuberonic acid (12OH-JA) after wounding originates partly through a sequential pathway involving (i) conjugation of JA to Ile, (ii) oxidation of the JA-Ile conjugate, and (iii) cleavage under the action of the amidohydrolases. The coordinated actions of oxidative and hydrolytic branches in the jasmonate pathway highlight novel mechanisms of JA-Ile hormone turnover and redefine the dynamic metabolic grid of jasmonate conversion in the wound response. << Less
J. Biol. Chem. 288:31701-31714(2013) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.