Enzymes
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- Name help_outline 4-hydroxy-L-threonine Identifier CHEBI:60904 Charge 0 Formula C4H9NO4 InChIKeyhelp_outline JBNUARFQOCGDRK-GBXIJSLDSA-N SMILEShelp_outline [NH3+][C@@H]([C@H](O)CO)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline glycolaldehyde Identifier CHEBI:17071 (CAS: 141-46-8) help_outline Charge 0 Formula C2H4O2 InChIKeyhelp_outline WGCNASOHLSPBMP-UHFFFAOYSA-N SMILEShelp_outline [H]C(=O)CO 2D coordinates Mol file for the small molecule Search links Involved in 17 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline glycine Identifier CHEBI:57305 Charge 0 Formula C2H5NO2 InChIKeyhelp_outline DHMQDGOQFOQNFH-UHFFFAOYSA-N SMILEShelp_outline [NH3+]CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 152 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:28779 | RHEA:28780 | RHEA:28781 | RHEA:28782 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.
Kim J., Kershner J.P., Novikov Y., Shoemaker R.K., Copley S.D.
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic path ... >> More
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathways. Mutations that increase expression or activity of enzymes in such serendipitous pathways can elevate flux through the pathway to a physiologically significant level. In this study, we describe the discovery of three serendipitous pathways that allow synthesis of pyridoxal-5'-phosphate (PLP) in a strain of E. coli that lacks 4-phosphoerythronate (4PE) dehydrogenase (PdxB) when one of seven different genes is overexpressed. We have characterized one of these pathways in detail. This pathway diverts material from serine biosynthesis and generates an intermediate in the normal PLP synthesis pathway downstream of the block caused by lack of PdxB. Steps in the pathway are catalyzed by a protein of unknown function, a broad-specificity enzyme whose physiological role is unknown, and a promiscuous activity of an enzyme that normally serves another function. One step in the pathway may be non-enzymatic. << Less
Mol Syst Biol 6:436-436(2010) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.