Reaction participants Show >> << Hide
- Name help_outline futalosine Identifier CHEBI:58863 Charge -1 Formula C19H17N4O7 InChIKeyhelp_outline VEDWXCWBMDQNCV-SCFUHWHPSA-M SMILEShelp_outline O[C@@H]1[C@@H](CCC(=O)c2cccc(c2)C([O-])=O)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,204 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline dehypoxanthine futalosine Identifier CHEBI:58864 Charge -1 Formula C14H15O7 InChIKeyhelp_outline XWPBBHHZDYSYMS-ZXRVKKJVSA-M SMILEShelp_outline OC1O[C@H](CCC(=O)c2cccc(c2)C([O-])=O)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline hypoxanthine Identifier CHEBI:17368 (Beilstein: 5811; CAS: 68-94-0) help_outline Charge 0 Formula C5H4N4O InChIKeyhelp_outline FDGQSTZJBFJUBT-UHFFFAOYSA-N SMILEShelp_outline O=c1[nH]cnc2nc[nH]c12 2D coordinates Mol file for the small molecule Search links Involved in 14 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:25904 | RHEA:25905 | RHEA:25906 | RHEA:25907 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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An alternative menaquinone biosynthetic pathway operating in microorganisms.
Hiratsuka T., Furihata K., Ishikawa J., Yamashita H., Itoh N., Seto H., Dairi T.
In microorganisms, menaquinone is an obligatory component of the electron-transfer pathway. It is derived from chorismate by seven enzymes in Escherichia coli. However, a bioinformatic analysis of whole genome sequences has suggested that some microorganisms, including pathogenic species such as H ... >> More
In microorganisms, menaquinone is an obligatory component of the electron-transfer pathway. It is derived from chorismate by seven enzymes in Escherichia coli. However, a bioinformatic analysis of whole genome sequences has suggested that some microorganisms, including pathogenic species such as Helicobacter pylori and Campylobacter jejuni, do not have orthologs of the men genes, even though they synthesize menaquinone. We deduced the outline of this alternative pathway in a nonpathogenic strain of Streptomyces by bioinformatic screening, gene knockouts, shotgun cloning with isolated mutants, and in vitro studies with recombinant enzymes. As humans and commensal intestinal bacteria, including lactobacilli, lack this pathway, it represents an attractive target for the development of chemotherapeutics. << Less
Science 321:1670-1673(2008) [PubMed] [EuropePMC]
This publication is cited by 5 other entries.