Reaction participants Show >> << Hide
- Name help_outline a 2-oxocarboxylate Identifier CHEBI:35179 Charge -1 Formula C2O3R SMILEShelp_outline [O-]C(=O)C([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 599 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline L-asparagine Identifier CHEBI:58048 Charge 0 Formula C4H8N2O3 InChIKeyhelp_outline DCXYFEDJOCDNAF-REOHCLBHSA-N SMILEShelp_outline NC(=O)C[C@H]([NH3+])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 27 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-oxosuccinamate Identifier CHEBI:57735 Charge -1 Formula C4H4NO4 InChIKeyhelp_outline ONGPAWNLFDCRJE-UHFFFAOYSA-M SMILEShelp_outline NC(=O)CC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 9 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline an L-α-amino acid Identifier CHEBI:59869 Charge 0 Formula C2H4NO2R SMILEShelp_outline [NH3+][C@@H]([*])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 372 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:19813 | RHEA:19814 | RHEA:19815 | RHEA:19816 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Specific form(s) of this reaction
Publications
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Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours.
Yamada T., Waller A.S., Raes J., Zelezniak A., Perchat N., Perret A., Salanoubat M., Patil K.R., Weissenbach J., Bork P.
Despite the current wealth of sequencing data, one-third of all biochemically characterized metabolic enzymes lack a corresponding gene or protein sequence, and as such can be considered orphan enzymes. They represent a major gap between our molecular and biochemical knowledge, and consequently ar ... >> More
Despite the current wealth of sequencing data, one-third of all biochemically characterized metabolic enzymes lack a corresponding gene or protein sequence, and as such can be considered orphan enzymes. They represent a major gap between our molecular and biochemical knowledge, and consequently are not amenable to modern systemic analyses. As 555 of these orphan enzymes have metabolic pathway neighbours, we developed a global framework that utilizes the pathway and (meta)genomic neighbour information to assign candidate sequences to orphan enzymes. For 131 orphan enzymes (37% of those for which (meta)genomic neighbours are available), we associate sequences to them using scoring parameters with an estimated accuracy of 70%, implying functional annotation of 16,345 gene sequences in numerous (meta)genomes. As a case in point, two of these candidate sequences were experimentally validated to encode the predicted activity. In addition, we augmented the currently available genome-scale metabolic models with these new sequence-function associations and were able to expand the models by on average 8%, with a considerable change in the flux connectivity patterns and improved essentiality prediction. << Less
Mol. Syst. Biol. 8:581-581(2012) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.