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RHEA:19621 a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)

Enzymes

UniProtKB ^help_outline	7,335 proteins
Enzyme class ^help_outline	EC 3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
GO Molecular Function ^help_outline	GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity

Reaction participants Show >> << Hide

Name ^help_outline a nucleoside 2',3'-cyclic phosphate Identifier CHEBI:66954 Charge -1 Formula C5H7O6PR SMILES^help_outline OC[C@H]1O[C@@H]([*])[C@@H]2OP([O-])(=O)O[C@H]12 2D coordinates Mol file for the small molecule Search links Involved in 12 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H₂O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) ^help_outline Charge 0 Formula H2O InChIKey^help_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILES^help_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,204 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline a nucleoside 3'-phosphate Identifier CHEBI:66949 Charge -2 Formula C5H8O7PR SMILES^help_outline OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 11 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H⁺ Identifier CHEBI:15378 Charge 1 Formula H InChIKey^help_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILES^help_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,431 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:19621	RHEA:19622	RHEA:19623	RHEA:19624
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline	7,335 proteins
EC numbers ^help_outline	3.1.4.16
Gene Ontology ^help_outline	GO:0008663
KEGG ^help_outline				R03423
MetaCyc ^help_outline		CYCPHOSDIESTER-RXN
EcoCyc ^help_outline		CYCPHOSDIESTER-RXN

Related reactions ^help_outline

Specific form(s) of this reaction

RHEA:27886
2',3'-cyclophospho-AMP + H₂O = 3'-AMP + H⁺
RHEA:27882
2',3'-cyclophospho-CMP + H₂O = 3'-CMP + H⁺
RHEA:27878
2',3'-cyclophospho-UMP + H₂O = 3'-UMP + H⁺
RHEA:27858
2',3'-cyclophospho-GMP + H₂O = 3'-GMP + H⁺

Publications

A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. II. FURTHER STUDIES ON SUBSTRATE SPECIFICITY AND MODE OF ACTION OF THE ENZYME.

ANRAKU Y.

J Biol Chem 239:3420-3424(1964) [PubMed] [EuropePMC]
A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. I. PURIFICATION AND SOME PROPERTIES OF THE ENZYME.

ANRAKU Y.

J Biol Chem 239:3412-3419(1964) [PubMed] [EuropePMC]
A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis.

Center M.S., Behal F.J.

J Biol Chem 243:138-143(1968) [PubMed] [EuropePMC]