Enzymes
| Enzyme class help_outline |
|
Reaction participants Show >> << Hide
- Name help_outline 3-[(Z)-2-isocyanoethenyl]-1H-indole Identifier CHEBI:140434 (CAS: 61168-06-7) help_outline Charge 0 Formula C11H8N2 InChIKeyhelp_outline JQMYMZZLIOIXEO-SREVYHEPSA-N SMILEShelp_outline C=12C(=CC=CC1)NC=C2/C=C\[N+]#[C-] 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (2E)-geranyl diphosphate Identifier CHEBI:58057 (Beilstein: 4549979) help_outline Charge -3 Formula C10H17O7P2 InChIKeyhelp_outline GVVPGTZRZFNKDS-JXMROGBWSA-K SMILEShelp_outline CC(C)=CCC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 61 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole Identifier CHEBI:140439 Charge 0 Formula C21H24N2 InChIKeyhelp_outline RDFHTLPPJOQCJA-DATWYKNKSA-N SMILEShelp_outline C(=C\[N+]#[C-])\C1(C/C=C(/CCC=C(C)C)\C)C=NC=2C1=CC=CC2 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) help_outline Charge -3 Formula HO7P2 InChIKeyhelp_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILEShelp_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,139 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:17349 | RHEA:17350 | RHEA:17351 | RHEA:17352 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
|
|||
| EC numbers help_outline | ||||
| KEGG help_outline | ||||
| MetaCyc help_outline |
Publications
-
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
Li S., Lowell A.N., Newmister S.A., Yu F., Williams R.M., Sherman D.H.
The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole- and fischerindole-type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug de ... >> More
The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole- and fischerindole-type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade. << Less
Nat Chem Biol 13:467-469(2017) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.