Reaction participants Show >> << Hide
- Name help_outline D-mannonate Identifier CHEBI:17767 Charge -1 Formula C6H11O7 InChIKeyhelp_outline RGHNJXZEOKUKBD-MBMOQRBOSA-M SMILEShelp_outline OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline NAD+ Identifier CHEBI:57540 (Beilstein: 3868403) help_outline Charge -1 Formula C21H26N7O14P2 InChIKeyhelp_outline BAWFJGJZGIEFAR-NNYOXOHSSA-M SMILEShelp_outline NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,186 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,431 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline keto-D-fructuronate Identifier CHEBI:59881 (Beilstein: 4138715) help_outline Charge -1 Formula C6H9O7 InChIKeyhelp_outline IZSRJDGCGRAUAR-WISUUJSJSA-M SMILEShelp_outline OCC(=O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline NADH Identifier CHEBI:57945 (Beilstein: 3869564) help_outline Charge -2 Formula C21H27N7O14P2 InChIKeyhelp_outline BOPGDPNILDQYTO-NNYOXOHSSA-L SMILEShelp_outline NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,116 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:15729 | RHEA:15730 | RHEA:15731 | RHEA:15732 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Prediction of enzymatic pathways by integrative pathway mapping.
Calhoun S., Korczynska M., Wichelecki D.J., San Francisco B., Zhao S., Rodionov D.A., Vetting M.W., Al-Obaidi N.F., Lin H., O'Meara M.J., Scott D.A., Morris J.H., Russel D., Almo S.C., Osterman A.L., Gerlt J.A., Jacobson M.P., Shoichet B.K., Sali A.
The functions of most proteins are yet to be determined. The function of an enzyme is often defined by its interacting partners, including its substrate and product, and its role in larger metabolic networks. Here, we describe a computational method that predicts the functions of orphan enzymes by ... >> More
The functions of most proteins are yet to be determined. The function of an enzyme is often defined by its interacting partners, including its substrate and product, and its role in larger metabolic networks. Here, we describe a computational method that predicts the functions of orphan enzymes by organizing them into a linear metabolic pathway. Given candidate enzyme and metabolite pathway members, this aim is achieved by finding those pathways that satisfy structural and network restraints implied by varied input information, including that from virtual screening, chemoinformatics, genomic context analysis, and ligand -binding experiments. We demonstrate this integrative pathway mapping method by predicting the L-gulonate catabolic pathway in <i>Haemophilus influenzae</i> Rd KW20. The prediction was subsequently validated experimentally by enzymology, crystallography, and metabolomics. Integrative pathway mapping by satisfaction of structural and network restraints is extensible to molecular networks in general and thus formally bridges the gap between structural biology and systems biology. << Less
Elife 7:e31097-e31097(2018) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.
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Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli.
HICKMAN J., ASHWELL G.
J Biol Chem 235:1566-1570(1960) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.
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Catabolism of galacturonic and glucuronic acids by Erwinia carotovora.
KILGORE W.W., STARR M.P.
J Biol Chem 234:2227-2235(1959) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.