Rhea - reaction knowledgebase

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Name ^help_outline ATP Identifier CHEBI:30616 (Beilstein: 3581767) ^help_outline Charge -4 Formula C10H12N5O13P3 InChIKey^help_outline ZKHQWZAMYRWXGA-KQYNXXCUSA-J SMILES^help_outline Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,280 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline (nucleoside 5'-monophosphate)_n Identifier CHEBI:140395 Charge -1 Formula (C5H7O6PR)n.H2O Search links Involved in 8 reaction(s) Find proteins in UniProtKB for this molecule Form(s) in this reaction:
- Identifier: RHEA-COMP:14527
  
  Polymer name: RNA_(n)
  
  Polymerization index ^help_outline n
  
  Formula H2O(C5H7O6PR)_n
  
  Charge (0)(-1)_n
  Mol File for the polymer
Name ^help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) ^help_outline Charge -3 Formula HO7P2 InChIKey^help_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILES^help_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,129 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline poly(RNA)-3'-adenine ribonucleotide polymer Identifier CHEBI:173115 Charge -2 Formula (C5H7O6PR)n.C10H13N5O7P Search links Involved in 2 reaction(s) Find proteins in UniProtKB for this molecule Form(s) in this reaction:
- Identifier: RHEA-COMP:17347
  
  Polymer name: RNA_(n)-3'-adenine ribonucleotide
  
  Polymerization index ^help_outline n
  
  Formula C10H13N5O7P(C5H7O6PR)_n
  
  Charge (-1)(-1)_n
  Mol File for the polymer

Cross-references

	RHEA:11332	RHEA:11333	RHEA:11334	RHEA:11335
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline	23,515 proteins	4,569 proteins
EC numbers ^help_outline	2.7.7.19
Gene Ontology ^help_outline	GO:1990817
KEGG ^help_outline				R00435
MetaCyc ^help_outline		POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN
EcoCyc ^help_outline		POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN

Publications

Ribonucleic acid-dependent ribonucleotide incorporation. I. Purification and properties of the enzyme.

AUGUST J.T., ORTIZ P.J., HURWITZ J.

J Biol Chem 237:3786-3793(1962) [PubMed] [EuropePMC]
Polynucleotide biosynthesis: formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei.

EDMONDS M., ABRAMS R.

J Biol Chem 235:1142-1149(1960) [PubMed] [EuropePMC]
The terminal nucleotidyltransferases of calf thymus nuclei.

Gottesman M.E., Canellakis E.S.

J Biol Chem 241:4339-4352(1966) [PubMed] [EuropePMC]

This publication is cited by 1 other entry.
Studies on the incorporation of deoxyribonucleic acid.

KRAKOW J.S., COUTSOGEORGOPOULOS C., CANELLAKIS E.S.

Biochim Biophys Acta 55:639-650(1962) [PubMed] [EuropePMC]

This publication is cited by 1 other entry.

RHEA:11334 diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n) Reaction with net flow from right to left. help_outline

Reaction participants Show >> << Hide

Cross-references

Publications

Ribonucleic acid-dependent ribonucleotide incorporation. I. Purification and properties of the enzyme.

Polynucleotide biosynthesis: formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei.

The terminal nucleotidyltransferases of calf thymus nuclei.

Studies on the incorporation of deoxyribonucleic acid.

RHEA:11334 diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n) Reaction with net flow from right to left. ^help_outline