Rhea - reaction knowledgebase

Enzymes

Enzyme class ^help_outline	EC 5.4.3.7 leucine 2,3-aminomutase
GO Molecular Function ^help_outline	GO:0050047 L-leucine 2,3-aminomutase activity

Reaction participants Show >> << Hide

Name ^help_outline L-leucine Identifier CHEBI:57427 Charge 0 Formula C6H13NO2 InChIKey^help_outline ROHFNLRQFUQHCH-YFKPBYRVSA-N SMILES^help_outline CC(C)C[C@H]([NH3+])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 45 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline (3R)-β-leucine Identifier CHEBI:57428 Charge 0 Formula C6H13NO2 InChIKey^help_outline GLUJNGJDHCTUJY-RXMQYKEDSA-N SMILES^help_outline CC(C)[C@H]([NH3+])CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:10284	RHEA:10285	RHEA:10286	RHEA:10287
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline
EC numbers ^help_outline	5.4.3.7
Gene Ontology ^help_outline	GO:0050047
KEGG ^help_outline				R01091
MetaCyc ^help_outline				LEUCINE-23-AMINOMUTASE-RXN

Publications

Leucine 2,3-aminomutase, an enzyme of leucine catabolism.

Poston J.M.

The initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by Clostridium sporogenes is the B12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). The amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is revers ... >> More

The initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by Clostridium sporogenes is the B12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). The amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is reversible and is inhibited by intrinsic factor. The enzyme activity has been found in several clostridia, in rat, sheep, rhesus, and African green monkey livers, and in human leukocytes. << Less

J Biol Chem 251:1859-1863(1976) [PubMed] [EuropePMC]

Comments

Published in: Freer, I., Pedrocchi-Fantoni, G., Picken, D.J. and Overton, K.H. Stereochemistry of the leucine 2,3-aminomutase from tissue-cultures of Andrographis paniculata. J. Chem. Soc. Chem. Commun. (1981) 80–82. Poston, J.M. Coenzyme B12-dependent enzymes in potatoes: leucine 2,3-aminomutase and methylmalonyl-CoA mutase. Phytochemistry 17 (1976) 401–402.