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- Name help_outline (2E,6E,10E)-geranylgeranyl diphosphate Identifier CHEBI:58756 (Beilstein: 3574726) help_outline Charge -3 Formula C20H33O7P2 InChIKeyhelp_outline OINNEUNVOZHBOX-QIRCYJPOSA-K SMILEShelp_outline CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 63 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (3E,7E)-dolathalia-3,7,11-triene Identifier CHEBI:138039 Charge 0 Formula C20H32 InChIKeyhelp_outline KDEVGDLVYKBTQM-WPNGSOMFSA-N SMILEShelp_outline C\C1=C/CC2(C)CCC(C)(C)C=C2CC\C(C)=C\CC1 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) help_outline Charge -3 Formula HO7P2 InChIKeyhelp_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILEShelp_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,139 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:54040 | RHEA:54041 | RHEA:54042 | RHEA:54043 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Identification of a dolabellane type diterpene synthase and other root-expressed diterpene synthases in Arabidopsis.
Wang Q., Jia M., Huh J.H., Muchlinski A., Peters R.J., Tholl D.
<i>Arabidopsis thaliana</i> maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which have been associated with direct and indirect defensive activities in flowers and leaves. In comparison, the str ... >> More
<i>Arabidopsis thaliana</i> maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which have been associated with direct and indirect defensive activities in flowers and leaves. In comparison, the structural diversity and function of terpenes in <i>Arabidopsis</i> roots has remained largely unexplored despite a substantial number of root-expressed genes in the <i>Arabidopsis</i> terpene synthase (<i>TPS</i>) gene family. We show that five root-expressed <i>TPSs</i> of an expanded subfamily-a type clade in the <i>Arabidopsis TPS</i> family function as class I diterpene synthases that predominantly convert geranylgeranyl diphosphate (GGPP) to different semi-volatile diterpene products, which are in part detectable at low levels in the ecotypes Columbia (Col) and Cape Verde Island (Cvi). The enzyme TPS20 produces a macrocyclic dolabellane diterpene alcohol and a dolabellane-related diterpene olefin named dolathaliatriene with a so far unknown C6-C11 bicyclic scaffold besides several minor olefin products. The TPS20 compounds occur in all tissues of Cvi but are absent in the Col ecotype because of deletion and substitution mutations in the Col TPS20 sequence. The primary TPS20 diterpene products retard the growth of the root rot pathogen <i>Pythium irregulare</i> but only at concentrations exceeding those <i>in planta</i>. Together, our results demonstrate that divergence and pseudogenization in the <i>Arabidopsis TPS</i> gene family allow for structural plasticity in diterpene profiles of above- and belowground tissues. << Less
Front. Plant Sci. 7:1761-1761(2016) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.