Enzymes
| UniProtKB help_outline | 3 proteins |
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Reaction participants Show >> << Hide
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Name help_outline
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)n
Identifier
CHEBI:141005
Charge
-2
Formula
(C5H6NO3)n.C14H15N6O3
Search links
Involved in 6 reaction(s)
Find proteins in UniProtKB for this molecule
Form(s) in this reaction:
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Identifier: RHEA-COMP:14738Polymer name: (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n)Polymerization index help_outline nFormula C14H15N6O3(C5H6NO3)nCharge (-1)(-1)nMol File for the polymer
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- Name help_outline sarcosine Identifier CHEBI:57433 Charge 0 Formula C3H7NO2 InChIKeyhelp_outline FSYKKLYZXJSNPZ-UHFFFAOYSA-N SMILEShelp_outline C[NH2+]CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 17 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
oxidized [electron-transfer flavoprotein]
Identifier
RHEA-COMP:10685
Reactive part
help_outline
- Name help_outline FAD Identifier CHEBI:57692 Charge -3 Formula C27H30N9O15P2 InChIKeyhelp_outline IMGVNJNCCGXBHD-UYBVJOGSSA-K SMILEShelp_outline Cc1cc2nc3c(nc(=O)[n-]c3=O)n(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)c2cc1C 2D coordinates Mol file for the small molecule Search links Involved in 182 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,717 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Name help_outline
(6R)-5,10-methylenetetrahydrofolyl-(γ-L-Glu)n
Identifier
CHEBI:136572
Charge
-2
Formula
(C5H6NO3)n.C15H15N6O3
Search links
Involved in 5 reaction(s)
Find proteins in UniProtKB for this molecule
Form(s) in this reaction:
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Identifier: RHEA-COMP:13257Polymer name: (6R)-5,10-methylenetetrahydrofolyl-(γ-L-Glu)(n)Polymerization index help_outline nFormula C15H15N6O3(C5H6NO3)nCharge (-1)(-1)nMol File for the polymer
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Namehelp_outline
reduced [electron-transfer flavoprotein]
Identifier
RHEA-COMP:10686
Reactive part
help_outline
- Name help_outline FADH2 Identifier CHEBI:58307 Charge -2 Formula C27H33N9O15P2 InChIKeyhelp_outline YPZRHBJKEMOYQH-UYBVJOGSSA-L SMILEShelp_outline Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)c2cc1C 2D coordinates Mol file for the small molecule Search links Involved in 173 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline glycine Identifier CHEBI:57305 Charge 0 Formula C2H5NO2 InChIKeyhelp_outline DHMQDGOQFOQNFH-UHFFFAOYSA-N SMILEShelp_outline [NH3+]CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 151 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:19793 | RHEA:19794 | RHEA:19795 | RHEA:19796 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
HOSKINS D.D., MACKENZIE C.G.
J Biol Chem 236:177-183(1961) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.
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Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
FRISELL W.R., MACKENZIE C.G.
J Biol Chem 237:94-98(1962) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.
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The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases.
Steenkamp D.J., Husain M.
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at t ... >> More
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at the end of the rapid phase of reduction of ETF is only about 10% less than without tetrahydrofolate, as judged by e.p.r. spectroscopy. Tetrahydrofolate does not alter the rate of reduction of ETF by either sarcosine or dimethylglycine dehydrogenase. Nevertheless, it was clearly demonstrated that tetrahydrofolate is a substrate for both sarcosine and dimethylglycine dehydrogenases and is converted to N5,10-methylenetetrahydrofolate. << Less
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Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins.
Wittwer A.J., Wagner C.
J. Biol. Chem. 256:4109-4115(1981) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.